XLS《Table1》

Table1.

TotalinteractionsbetweenHBVandhumanproteinscataloguedfromtorelatedliterature. , Pubmed_ID , HBV_gene_mention , HBV_gene , verb_mention , verb , human_gene_mention , human_official_gene_symbol , human_gene_entrez_ID , human_official_gene_description , sentence , PubMed_link

18309246 , HBx , Xprotein , repressed , repress , CDK2 , CDK2 ,

1017 , cyclin-dependentkinase2 , Moreover,HBxinductionrepressedcellgrowthanddownregulatedtheexpressionsofcyclinD1,CDK4,cyclinE,CDK2,andcyclinB1. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=18309246[uid]

18309246 , HBx , Xprotein , repressed , repress , CDK4 , CDK4 ,

1019 , cyclin-dependentkinase4 , Moreover,HBxinductionrepressedcellgrowthanddownregulatedtheexpressionsofcyclinD1,CDK4,cyclinE,CDK2,andcyclinB1. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=18309246[uid]

18602370 , HBx , Xprotein , regulated , regulate , WAF1 , CDKN1A ,

1026 , cyclin-dependentkinaseinhibitor1A(p21,Cip1) , TheexpressionofP53,p21(WAF1),p14(ARF),andMDM2proteinswasregulatedbyexpressionofHBxmutants. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=18602370[uid]

15248906 , HBx , Xprotein , inhibit , inhibit , WAF1 , CDKN1A ,

1026 , cyclin-dependentkinaseinhibitor1A(p21,Cip1) , CONCLUSION:HBxmaynotonlyincreasetheexpressionofp21(WAF1)byintroducingtheaccumulationofp53incytoplasmbutalsoinhibitthetranscriptionalactivityofp21(WAF1)promoterinap53-independentmanner. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=15248906[uid]

11997040 , coreprotein , coreprotein , repression , repress , cyclin-dependentkinaseinhibitorp21 , CDKN1A ,

1026 , cyclin-dependentkinaseinhibitor1A(p21,Cip1) , Cooperativerepressionofcyclin-dependentkinaseinhibitorp21geneexpressionbyhepatitisBvirusXproteinandhepatitisCviruscoreprotein. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=11997040[uid]

17575144 , HBx , Xprotein , repress , repress , p16(INK4a) , CDKN2A ,

1029 , cyclin-dependentkinaseinhibitor2A(melanoma,p16,inhibitsCDK4) , HBxinducedDNAhypermethylationofp16(INK4a)promotertorepressitsexpression,whichsubsequentlyledtoactivationofG1-CDKs,phosphorylationofpRb,activationofE2F1,andfinallytranscriptionalactivationofDNMT1. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=17575144[uid]

18602370 , HBx , Xprotein , regulated , regulate , ARF , CDKN2A ,

1029 , cyclin-dependentkinaseinhibitor2A(melanoma,p16,inhibitsCDK4) , TheexpressionofP53,p21(WAF1),p14(ARF),andMDM2proteinswasregulatedbyexpressionofHBxmutants. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=18602370[uid]

18032378 , HBx , Xprotein , interaction , interact , HBXIP , HBXIP ,

10542 , hepatitisBvirusxinteractingprotein , TounderstandthecarcinogenicmechanismofhepatitisBvirus-encodedoncoproteinHBx,weexploredthefunctionofHBxinteractionwithitscellulartargetHBXIP. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=18032378[uid]

16982752 , HBx , Xprotein , associateswith , associate , HBXIP , HBXIP ,

10542 , hepatitisBvirusxinteractingprotein , ImmunolocalizationandfluorescentproteintaggingexperimentsshowedthatHBXIPassociateswithmicrotubulesofdividingcellsandcolocalizeswithHBxoncentrosomes. , http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&

cmd=search&

term=16982752[uid]

18032378 , HBx , Xprotein , Interaction , Interact , HBXIP , HBXIP ,