PDF《microvascular function》

ORIGINAL ARTICLE The impact of obesity on the relationship between epicardial adipose tissue, left ventricular mass and coronary microvascular function M.

J. Bakkum1 & I. Danad1 & M. A. J. Romijn1 & W. J. A. Stuijfzand1 & R. M. Leonora1 & I. I. Tulevski2 & G. A. Somsen2 & A. A. Lammertsma3 & C. van Kuijk3 & A. C. van Rossum1 & P. G. Raijmakers3 & P. Knaapen1 Received:

13 November

2014 /Accepted:

11 May

2015 /Published online:

9 June

2015 # The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Purpose Epicardial adipose tissue (EAT) has been linked to coronary artery disease (CAD) and coronary microvascular dysfunction. However, its injurious effect may also impact the underlying myocardium. This study aimed to determine the impact of obesity on the quantitative relationship between left ventricular mass (LVM), EATand coronary microvascular function. Methods A total of

208 (94 men,

45 %) patients evaluated for CAD but free of coronary obstructions underwent quantitative [15 O]H2O hybrid positron emission tomography (PET)/CT imaging. Coronary microvascular resistance (CMVR) was calculated as the ratio of mean arterial pressure to hyperaemic myocardial blood flow. Results Obese patients [body mass index (BMI)>25, n=133,

64 % of total] had more EAT (125.3±47.6 vs 93.5±42.1 cc, p