PDF《Lithium》

72 h after traumatic injury to rat brain. Fig. (1): The two calpain ( amd m) isoforms exist as heterodimers, each with a defined catalytic subunit and a small regulatory subunit common to both iso- forms. In the calpain isoform 2, the catalytic subunit of m-calpain contains an anchor domain I at the N-terminal end. The catalytic region is in domain II. The role of domain III is virtually unknown and domain IV is the calcium-binding domain. This subunit consists of two domains, the N-terminal hydrophobic domain V, which is rich in residues of glycine, and the C-terminal domain VI, which, like the domain of the V catalytic subunit, is the calcium-binding region[4]. Various immunohistochemical studies have been car........